A PROTAC-based molecule called “Nb-PROTACs” has been developed that increased the survival rate of H1N1 virus-infected mice to 90%. The compound degrades viral nucleoprotein and produced an 80% survival rate in mice infected with H5N1. Its effectiveness against 16 types of influe
2026-05-20
An ASO targeting SNRPF, a key oncogenic factor in ovarian cancer, was found to inhibit tumor growth. The ASO disrupts the “SNRPF-DDX24-E2F4” feedback loop, sequentially reducing expression of the DDX24 and E2F4 genes. Its efficacy was also demonstrated in in vivo and patient-deri
2026-05-20
A Yale University research team found that garlic acts as a “natural contraceptive,” reducing the mating rate of Aedes albopictus from 62.5% to 0%. The mechanism involves diallyl disulfide, garlic’s key compound, acting on the female mosquito’s taste receptor TrpA1 at a concentra
2026-05-20
Takeda lost a lawsuit over the delayed launch of a generic version of the constipation drug Amitiza and was ordered to pay $885 million, or approximately $1.28 billion. The jury found Takeda liable for conspiring with a competitor to delay the generic launch until 2021. Damages c
2026-05-19
A newly identified cellular organelle, the hydrogenosome, could reduce methane emissions from cows’ stomachs by more than 30%. The organelle was found to promote the production of methane, a greenhouse gas 28 times more potent than carbon dioxide. Researchers plan to develop feed
2026-05-19
The metabolite butyrate produced by gut microbes was found to ease chronic temporomandibular joint pain, which affects 5% to 12% of the global population. In an animal study, butyrate reversed pain-related abnormalities in gene expression in a specific brain region and improved p
2026-05-19
Duke researchers have published the ‘LinCx’ technology in Nature, using two fish-derived proteins (connexin 34.7 and 35) to create electrical connections between specific neurons. The technology forms artificial electrical synapses that do not react with mammalian proteins and bi
2026-05-19
Occupational therapists have been appointed as secretary-general and deputy center director at two dementia relief centers, emerging as key leaders in dementia policy. The appointments are viewed as an expansion of occupational therapists’ expertise into policy and administration
2026-05-19
Low-dose decitabine-treated CAR-T cells (dCAR-T) demonstrated potent antitumor activity against solid tumors expressing two or more antigens. dCAR-T cells secrete large amounts of interferon-γ (IFN-γ), inducing the death of antigen-negative cells and activating dendritic cells. T
2026-05-19
A 21-amino acid peptide from the capsid protein of porcine circovirus type 2 (PCV2) has opened up the possibility of a universal vaccine platform. The nanoparticle works by activating cellular autophagy and tumor necrosis factor (TNF-α) signaling, thereby enhancing antigen presen
2026-05-19
