Study Identifies How p53-Mutant Cancers Evade T-Cell Attack

Researchers at Dana-Farber Cancer Institute in the United States identified how mutations in the p53 tumor suppressor protein enable cancer cells to evade T-cell attack.

The researchers found that p53 targets are not sufficiently displayed on the cell surface for detection: Only five of 175 predicted peptide candidates were actually detected.

They experimentally demonstrated that inhibiting the ERAP1 enzyme enables p53-specific T cells to recognize the cancer cells again.