Bio News
Resistance to PD-1 inhibitors in esophageal squamous cell carcinoma is associated with reduced MHC I antigen presentation, with loss of the transcription factor KLF4 identified as a key cause. KLF4 activates MHC I gene expression by maintaining chromatin accessibility and assembling the enhanceosome, and this mechanism is impaired in more than half of patients. Reinducing KLF4 with APT-253 restored the tumors’ sensitivity to immunotherapy.
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biobookmedia@biobook.co.krParagon Spin-Off Velaris Goes Public Through Reverse Merger With Alaunos
Syndax halts development of Niktimvo for pulmonary fibrosis; shares plunge 17%
BioNTech’s mRNA Cancer Vaccine Misses Primary Endpoint for Progression-Free Survival in Phase 3 Trial
Roche Signs $1.6 Billion Deal With China’s Rona for ALK7 Obesity Drug
Formycon and Zydus’ Keytruda Biosimilar Is First to Be Accepted for FDA Review
Pfizer Signs $500 Million Protein Degrader Deal With Enodia
